“We have applied a precision IO approach by targeting specific Vβ-chain variants of the TCR, to activate subsets of a patient’s own T cells. As a result, a patient’s T cells are able to ...

During this trial, activated T-cells were engineered to target disialoganglioside 2 (GD2), a protein often overexpressed in neuroblastoma cells. This therapy involved both activated T-cells (ATCs ...

New research shows how a specially trained population of immune cells keeps the peace by preventing other immune cells from attacking their own. The study provides a better understanding of immune ...

OX40R is a co-stimulatory molecule expressed on activated effector and memory T cells, and OX40R-positive T cells release pro ...

Balancing the immune system is a delicate act. If it’s too weak, infections and cancer can take hold; if it’s too strong, autoimmune diseases or transplant rejection can occur. Researchers have ...

Our immune system works to fight infections immediately, but also maintain long-term immunity. Two waves of protection help neutralize and eliminate diseas | Immunology ...

For the 80 million people worldwide with celiac disease, the only treatment available is to cut grains like pasta and bread out of their lives. | For the 80 million people worldwide who have celiac ...

6 In 1969, fluorescence activated cell sorting (FACS ... where his team and others use FACS to identify rare antigen-specific T and B cells. “It’s absolutely critical,” he said. For example, his team ...

Given these promising results and a strong scientific rationale, combined with LX-101’s novel mechanism of action and prior positive clinical experience in oncology, Lirum is planning new clinical ...

Additional Phase 2 data for vilastobart,a tumor-activated, Fc-enhanced anti-CTLA-4, in combination with atezolizumab in patients with MSS CRC ...