If you're looking to make one that's a bit smarter, DIYer Samuel Clay built a digital photo frame that uses a Raspberry Pi to connect it to the internet so it's always getting up to date pictures ...

The PQ Labs Multi-Touch G4 frame is a 32 inch or larger overlay frame that you can use with a projector or TV display to add support for multi-touch input. Prics for the frames start at about $467 .