During antigen recognition, CD4 or CD8 molecules act as co-receptors ... meaning they can recognize more than one peptide-MHC 1. Why is high-throughput multi-dimensional T cell profiling important?

Some recent studies have suggested that T cells can become activated via recognition of donor MHC molecules transferred ... Following allorecognition, CD4 + and CD8 + T cells become activated ...

class II molecules and prompt a helper CD4+ immune response, whereas antigens derived from cytosolic peptides are presented on MHC class I molecules and tend to induce a killer CD8+ immune response.

They do so by using MHC-II to instruct a different subset of CD4 + T RM cells in the airways to produce a cytokine IFN-gamma, which then potently suppressed inflammation in this mouse model of ...