The thymus functions as the primary lymphoid organ responsible for the generation of T cells and plays a crucial role in preventing autoimmune reactions by eliminating autoreactive cells before ...

Signaling molecules involved in central tolerance were inhibited; upon closer examination, the scientists saw that this stemmed from CXCL4 binding to and preventing the delivery of DNA fragments ...

Scientists at Stanford University School of Medicine, Yale University School of Medicine, and the Hospital for Special Surgery Research Institute have discovered new insights into how the immune ...

More information: Elif Çakan et al, TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance, Journal of Experimental Medicine (2023). DOI: 10.1084/jem.20230944 .

By setting a clear impact tolerance for your most important business services, you’re helping your organization draw a line in the sand and crystalize your resilience objectives. The impact tolerance ...

This process, known as central tolerance, is thought to be controlled by B cell receptors (BCRs) on the surface of the developing B cells.