Vasopressin is known to exacerbate ADPKD cysts from collecting ducts, and when it was administered to the induced collecting ducts and renal tubules, cysts formed, albeit at a low frequency, only ...

Nephrogenic diabetes insipidus (NDI) is caused by inability of the kidneys to respond to arginine vasopressin and concentrate urine by reabsorption of water in the collecting duct. The disease can ...

Urine osmolality in control rats was 1670±198 mOsm per kg H2O, and immunocytochemistry revealed the presence of AQP2 in the apical plasma membrane of the principal cells in the collecting ducts.

Joint research, led by Kumamoto University in Japan, has successfully reproduced the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) from human iPS cells in vitro.

Loops of Henle and collecting ducts of the nephrons (Fig 3); Blood vessels of the vasa recta (Song and Yosypiv, 2012). Filtrate formed by the nephrons drains through these pyramids, via the renal ...

Collecting ducts derived from iPS cells with the heterozygous PKD1 gene mutation, ... and ureteric buds differentiate into the collecting ducts that collect urine and reabsorb water.

These interconnections are essential because urine produced by the nephrons must pass through the collecting ducts and into the ureter on its way to the bladder for excretion.

Reference: Zeng Z, Huang B, Parvez RK, et al. Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors. Nat Commun.

At later stages, they wrote, the ureteric bud organoids differentiate into collecting duct organoids, which contain >95% collecting duct cell types. This was determined through single-cell RNA ...

Now, a Japanese research group has developed a method of using PSCs to induce production of ureteric buds, the progenitors of branched collecting ducts, and has succeeded in reproducing the higher ...