Activation of T cells by antigen-presenting cells requires the formation of an immunological synapse, which involves ... T cells that is controlled by CRTAM (MHC-class-I-restricted T-cell ...
When naive T cells encounter antigen-presenting cells (APCs), membrane and cytoplasmic molecules rearrange at the T cell–APC contact area to form the immune synapse. Finetti et al. now reveal an ...
The interaction between CD2 and CD58 is critical for forming the immunological synapse, which is pivotal in immune cell activation and adhesion, as well as signaling in both immune and target cells.
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