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First-ever ribosomal synthesis of cyclic peptides opens new avenues for next-generation drug design
Inside our cells, ribosomes—the tireless "protein factories" of life—have just shown off a new skill they haven't used in billions of years. A research team has become the first in the world to ...
Binding of NucC trimers to a cyclic tri-adenylate second messenger promotes assembly of a NucC homohexamer competent for non-specific double-strand DNA cleavage. In infected cells, NucC activation ...
It’s harder for proteases to break down cyclic structures,” Mulligan says. This molecule is too big. Larger, protein-based drugs, such as antibodies, don’t have the same luxury of stability.
Japanese scientists have - for the first time - developed an efficient way to make organic molecules that have so far been difficult to synthesize because of their overall bulky structure and ...
Chemists have realized the synthesis of giant cyclic molecules using various approaches not only to create beautiful structures but also to compete in the elegance of the process of synthesizing ...
Scientists have unveiled an innovative approach for synthesizing azaparacyclophanes (APCs), a class of highly advanced ring-shaped molecular structures with immense potential in material science.
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