Further mutational studies identified a ten-membered intermediate shunt product from the mutant PcTS1 I254A, supporting the cyclization mechanism that begins with 1,10 cyclization in PcTS1.

Contemporaneously, this mechanism was recognized by others, and a model study was reported (see Peroxycyclization Model Study) in which one-electron oxidation of an allylic hydroperoxide produces ...

By examining the reaction conditions and uncovering the reaction mechanism, ... which then undergoes intramolecular cyclization, ultimately leading to the formation of 6-(difluoromethyl ...