Replication fork components The RF is a multiprotein complex with helicase and DNA synthesis activities. It is called a fork because the structure resembles a two-pronged fork.

Despite the importance of DNA replication, numerous aspects of this process are still poorly understood. One fundamental question is: how do replication forks efficiently progress through chromatin?

Led by Dr. Tomomi Tsubouchi at the National Institute for Basic Biology (NIBB) in Japan, the research team explored replication fork dynamics—such as replication fork speed, pausing frequency ...