Druggability — the likelihood of being able to modulate a target with a small-molecule drug — is crucial in determining whether a drug discovery project progresses from 'hit' to 'lead'.

Polypharmacology allows scientists to explore novel therapeutic purposes for existing drugs and opens new doors to treat ...

Unexpected drug side effects may often be attributed to actions on additional targets (off-targets) to those for which they were designed for. Now, writing in Science, Campillos and colleagues ...

Scientists engaged in precision medicine research focus intensely on target-based drug development. In doing so, they help improve the safety and efficacy profiles of future therapies by reducing ...

The Targets, Structures and Drugs (TSD) Research Program is comprised of faculty members at Purdue University with the mission to accelerate the discovery, development, and evaluation of small ...

Inc., a leader in the discovery of small molecule drugs for traditionally "hard-to-drug" targets, announced today a strategic collaboration and licensing agreement with Takeda. Under the terms of ...