This test uses a mouse's natural preference to stay in dark and narrow places (closed arms). ... The Elevated Plus Maze Test (IMAGE) Kumamoto University. Caption.

Typically, it has been difficult to test anxiogenic drugs in the elevated plus-maze due to the low baseline level of open arm exploration (10–20% open arm time) that is difficult to reduce further.

These studies demonstrate that neurokinin NK1 receptor antagonists produce anxiolytic-like effects in a novel gerbil elevated plus-maze, and suggest that this is an appropriate model to test NK1 ...

Using the 'elevated plus maze' test with mice, Japanese researchers have shown that Matcha green tea can reduce anxiety. Their experiments revealed that Matcha's anxiolytic effects are due to the ...