In this diagram of G-protein-coupled receptor activation, the alpha, beta, and gamma subunits are shown with distinct relationships to the plasma membrane. After exchange of GDP with GTP on the ...

G-protein coupled receptors (GPCRs) ... Now, the GDP-αβγ complex, with the involvement of Mg 2+, exchanges GTP in the bound GDP with the cytosol to develop a GTP-αβγ complex.

Reaction Bio’s suite of assays includes a nucleotide exchange assay, which detects SOS1/2-mediated exchange of fluorescently labeled GDP to GTP, as well as protein-protein interaction assays to ...