The hedgehog (Hh) signaling pathway regulates the differentiation and growth of numerous cell types, including chondrocytes, and thus is essential for normal skeletal development. Pharmacological ...

pathway are crucial to basal cell carcinoma (BCC) tumorigenesis. Primary cilia have emerged as key organelles in Hh signal transduction in mammalian systems and play a role in BCC. The requirement ...

This study fills a crucial gap in our understanding of blood cell formation from human pluripotent stem cells (hPSCs). Genome-wide comparisons of hPSC-derived blood progenitor cells with in vivo blood ...

The researchers identified markers for stem cell populations that maintain distinct regions of the meibomian glands, and ...

New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, promote liver fat accumulation, and impair ...

A study in mice reveals key interactions between proteins involved in fibroblast growth factor signaling and how they contribute to distinct stages of eye lens development.