During infections, the immune system needs to distinguish foreign antigens that are expressed by invading bacteria and ...

Gene expression is regulated by transcription factors in concert with epigenetic modifications (such as DNA methylation, post-translational histone modifications, the position and compaction of ...

CD8 T cells lacking Tet1/3 preferentially differentiate into short-lived effector and effector memory cells following acute ...

The research team profiled more than 47,000 T cells including acutely infected, treated, and uninfected cells, to then identify helper T cells (which detect infections), memory cells, naïve cells ...

Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression. Ferroptosis, driven by excessive lipid peroxides and iron-dependent reactive ...

A study shows that the semi-synthetic bile acid NorUDCA inhibits in the intestine the formation of pro-inflammatory T helper 17 cells (TH17) and at the same time promotes the generation of anti ...

The same team of scientists also showed that KROS 101 increased the proliferation of helper and cytotoxic T cells (CD4+ and CD8+), while decreasing T reg cell growth in a melanoma model.

B-cell acute lymphoblastic leukemia (B-ALL) is a life-threatening and highly aggressive form of blood cancer. It is the most ...

The effect of targeting only T cells expressing the OX40 receptor in AD, a T helper 2 (Th2)–mediated inflammatory disease, might be relevant to other Th2-mediated disorders, Guttman-Yassky ...