Kanazawa University and colleagues have developed a promising new approach to cancer treatment. By using tiny, naturally ...

Imagine a super-charged immune cell that can launch a focused attack on stubborn solid tumors -- a smart fighter that destroys cancer cells for days without tiring. Biomedical engineers have made this ...

Immunological synapse (IS) formation is a key part of developing and sustaining immune responses against cancer and is necessary for T cells and NK cells to eliminate tumor cells. This webinar will ...

In contrast, cancer cells often evade detection by displaying very few suspicious proteins that the immune system can identify and target. A new approach to cancer treatment, developed by ...

Cancer immunotherapies, including cancer vaccines, harness and amplify the immune system’s natural ability to detect and attack cancer cells. In this illustration, immune T cells (pink) attach to a ...

“By inducing immune synapse components to form at the site of CAR binding to target tumor cells we dramatically improve cytotoxicity while also delivering productive signals to the CAR via CD2 ...

Because tumor cells are known to induce T-cell tolerance ... modification of the CAR transmembrane domain to enhance the immune synapse, offers an avenue for enhancing CAR-T therapy.

The interaction between CD2 and CD58 is critical for forming the immunological synapse, which is pivotal ... regulation of autoimmune diseases, tumor immune evasion, antiviral responses, and ...

Leuven, 11 March 2025 – Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven ...

cells play a central role in immune responses against intracellular pathogens and tumors. CTLs and NK cells kill by forming a stereotyped interface with their targets, known as a cytolytic ...