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Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS. Journal of Cell Biology , 2022; 221 (12) DOI: 10.1083/jcb.202201024 Cite This Page : ...
For example, nuclear size and shape is also governed by emerin, which binds to lamins at the nuclear envelope (NE) and upon lamin loss is retained in the endoplasmic reticulum.
Kanazawa University, have discovered how a protein called lamin A helps repair the protective barrier around a cell's DNA.
Naturally occurring mutations within the LMNA gene, which encodes nuclear lamin, have been identified in patients with three rare and apparently unrelated diseases. Understanding how these ...
For instance, they found that rapid repair did not occur or was weakened in lamin C mutants, namely R435C, R471C, R527H, A529V, and K542N, compared to wild type (control) lamin C that did not have ...
In a recent study published in Nature Cell Biology, a team of researchers discovered that the elevated expression of lamin-associated polypeptide 1 (LAP1), an inner nuclear membrane protein, helps ...
De Novo Variants in LMNB1 Cause Pronounced Syndromic Microcephaly and Disruption of Nuclear Envelope Integrity. The American Journal of Human Genetics , 2020; DOI: 10.1016/j.ajhg.2020.08.015 Cite ...
The nuclear envelope (NE) is a vital barrier that protects the cell's genetic material. It is supported by the nuclear lamina (NL), a fibrous protein network composed of lamins, including lamin A ...
For instance, they found that rapid repair did not occur or was weakened in lamin C mutants, namely R435C, R471C, R527H, A529V, and K542N, compared to wild type (control) lamin C that did not have ...
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