This protocol refines co-immunoprecipitation (co-IP) for lipid droplet (LD)-specific protein interactions by isolating ...

Proteomics. 16(21), 2759-2763. Currie, E et al. (2014) High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol ...

(2016) Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism. J. Lipid Res. 58:226–235. Kory N, Farese RV Jr**, Walther TC** ...

Researchers from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences demonstrated the role of lipid droplet-localized CETN-SPDL1-L in the regulation of cone cell ...

This study investigates the role of the protein FIT2, a key protein in lipid droplet biogenesis, in LD accumulation within microglia and BAMs in an AD mouse model. They show that LDs accumulate with ...

When the researchers expressed the gene in white fat cells in mice, it was able to prevent the lipid droplets from merging into one large lipid droplet, according to the study.

The authors highlight recent advances in combining droplet microfluidics with MS for single-cell proteomics. Technologies like nanoPOTS, SODA, and OAD chip allow multistep sample preparation on a ...

This in turn allowed the team to visualize lipid droplet accumulation in mouse and fly test subjects, and characterize the role of particular protein pathways in regulating how lipid droplets behave.

To answer this question, the team looked directly at lipid droplets in the brains of mice with excess tau protein. They used a state-of-the-art SRS imaging platform developed in Lingyan Shi's lab ...