CIRCUMSCRIBED pretibial myxedema is an unusual but not a particularly rare skin disease. ... A certain relation seems to exist between localized myxedema and exophthalmos, ...

Pretibial myxedema, also called thyroid dermopathy or localized myxedema, is characterized by asymptomatic, cutaneous induration of the skin attributable to accumulation of acid ...

To the Editor: An interesting point concerning reflex changes in myxedema was raised by Dr. Sanders's article, "Neurologic Manifestations of Myxedema," in the March 22 issue of the Journal. "Refle ...

Changes of the skin in myxedema are thought due to changes in its composition of acid mucopolysaccharides (AMPS). In the skin of the hypothyroid rat it has been shown that the content of ...