The San Francisco 49ers have had a devastating season with regards to injuries to their running backs. They were down to their third string running back on Sunday, Isaac Guerendo, and he suffered ...

Running back Isaac Guerendo is officially active for the the 49ers' pivotal "Thursday Night Football" game against the Los Angeles Rams despite dealing with a foot injury on a short week.

The San Francisco 49ers’ running back problems aren’t getting any better. 49ers head coach Kyle Shanahan confirmed Monday that Isaac Guerendo sustained a foot sprain in Sunday’s 38-13 win ...