T cells use the T cell antigen-receptor (TCR) to recognize their antigens, which are often in the form of peptides bound to major histocompatibility complex molecules (MHC), also called HLA (human ...

By performing an integrative analysis with public datasets, they identified MHC class II genes ... factors and identified several candidate signaling pathways that may contribute to the induction ...

Recently developed major histocompatibility complex (MHC) multimer technologies allow visualization and isolation of antigen-specific T cells. However, functional analysis and in vivo transfer of ...

T cell activation requires a T cell receptor (TCR) to recognize its cognate peptide in the context of an MHC molecule. In addition, the association of CD3 with the TCR–peptide–MHC complex ...

The high determinant density model, in which the structure of the allogeneic MHC molecule governs T-cell recognition; [34] The multiple binary complex model, in which alloantigen recognition is ...