An intracellular sensor that tracks the quality of so-called MHC-I molecules which aid the immune system in identifying and eliminating dangerous cells, including tumor cells has been discovered ...

However, predicting their preferences for protein fragments, or peptides, has long been challenging due to the human population’s diverse range of MHC-1 molecules. Leveraging the power of AI and ...

Macbecin II was identified as a compound that upregulates MHC-I expression, enhancing immune-mediated cancer cell killing. In ...

Figure 1: Three pathways for loading major histocompatibility complex (MHC) class II molecules with peptides in dendritic cells. The presence of empty class II molecules on the surface of ...

T cells use the T cell antigen-receptor (TCR) to recognize their antigens, which are often in the form of peptides bound to major histocompatibility complex molecules (MHC), also called HLA (human ...

A novel mouse model offers definitive evidence that a single inhibitory receptor family governs the critical natural killer cell functions of licensing and missing-self.