It is known that CX3C chemokine receptor 1 (CX3CR1) expressed on macrophages plays a crucial role in inner hair cell ribbon synaptic repair and spiral ganglion neuron survival after synaptopathic ...

These are spiral ganglion neuron projections (red and yellow) from an isolated portion of a mouse cochlea. Cell bodies of neurons and inner hair cells are in green.

Hearing loss is a common affliction associated with advancing age and exposure to very loud noises, affecting two-thirds of adults over age 70. But living with hearing loss may not be inevitable.

Diminished macrophage accumulation in the DRG and SCG of Ccr2 -/- mice was found compared to WT ganglia 7 d after nerve injury. Interestingly, neutrophils were found in the SCG but not in the DRG.