The study suggests a potential benefit of routine multidose methotrexate treatment for recurrent cases of ectopic pregnancy.

The authors found that patients in the high methotrexate category had a significantly lower lumbar spine z score, a measure of BMD, compared with the low/intermediate group (–0.86 vs –0.14; P ...

Phase III Trial Comparing Two Dose Levels of Epirubicin Combined With Cyclophosphamide With Cyclophosphamide, Methotrexate, and Fluorouracil in Node-Positive Breast Cancer. JCO 19 , 3103-3110 (2001).

Methotrexate is a slow-acting disease-modifying antirheumatic drug (time to maximum therapeutic response is approximately 6 months), and delayed dose escalation might result in a loss of efficacy ...