The study suggests a potential benefit of routine multidose methotrexate treatment for recurrent cases of ectopic pregnancy.

One 5-mg reduction in the dose of methotrexate or its placebo was allowed for patients whose serum aminotransferase concentrations increased to at least 2.5 times the upper limit of the normal range.

Phase III Trial Comparing Two Dose Levels of Epirubicin Combined With Cyclophosphamide With Cyclophosphamide, Methotrexate, and Fluorouracil in Node-Positive Breast Cancer. JCO 19 , 3103-3110 (2001).