Dr. Mears’s previous research has focused on Dnm1, the yeast DRP involved in mitochondrial fission. Using cryo-EM and image reconstruction techniques, he has examined the structure of Dnm1-lipid tubes ...

Mitochondrial Fission, Fusion, and Mitophagy in Breast Cancer Mitochondrial dynamics—governed by fission (Drp1, Fis1) and fusion (MFN1/2, OPA1) proteins—regulate cellular homeostasis and are ...

Mitochondrial fission factor (MFF) works by recruiting a secondary protein (DRP1) to the mitochondria to encourage division. However, the molecular details of how this happens are not fully ...

Surprise Finding About Mitochondrial Fission and Fusion. But how do the two distinct subpopulations come about in the first place? Here’s where the story gets even more fascinating.

Diabetic nephropathy (DN), characterized by progressive damage to the glomeruli and tubulointerstitial compartments, is driven by metabolic reprogramming and mitochondrial dysfunction, including ...

“These beneficial effects of RalA deletion were driven by a reversal of the increased mitochondrial fission in white adipocytes induced by feeding mice HFD,” the team explained.

The dynamin family of GTPases regulate mitochondrial fission and fusion processes and have been implicated in controlling the release of caspase activators from mitochondria during apoptosis. Here we ...