A skeletal muscle-specific Ppm1k knockout (KO) mouse model was used to examine the effects of disrupted BCAA catabolism on sarcopenia. The model revealed that impaired BCAA catabolism influences ...

The primary driver is an imbalance between catabolism (the breakdown of tissues such as muscle or fat) and anabolism (the build-up of tissue). This imbalance occurs against a backdrop of poor ...