By connecting with its tumor-associated overexpression ligands, such as MICA, MICB, and ULBPs, NKG2D, an activating NK cell receptor can modulate the cytotoxic capability of NK cells against ...

A relevant example is the fairly recent evolution of entirely different types of NK cell receptors in mice and humans, who last shared a common ancestor around 65 million years ago; mouse NK cells ...

A novel mouse model offers definitive evidence that a single inhibitory receptor family governs the critical natural killer cell functions of licensing and missing-self.

RTX-240 increased the number of NK cells with specific receptor signatures associated with cytotoxicity and cytokine production in patients with solid tumors. “The pattern of NK cell receptor ...

Following the discovery of inhibitory KIR and the understanding that they play a role in preventing NK cell killing of self MHC I-expressing tumor cells, investigators began to research the ...