By connecting with its tumor-associated overexpression ligands, such as MICA, MICB, and ULBPs, NKG2D, an activating NK cell receptor can modulate the cytotoxic capability of NK cells against ...

A relevant example is the fairly recent evolution of entirely different types of NK cell receptors in mice and humans, who last shared a common ancestor around 65 million years ago; mouse NK cells ...

Following the discovery of inhibitory KIR and the understanding that they play a role in preventing NK cell killing of self MHC I-expressing tumor cells, investigators began to research the ...

offering a strategy for improving NK cell-based cancer immunotherapies. A major challenge in developing chimeric antigen receptor (CAR)-engineered cell therapies for acute myeloid leukemia (AML ...

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