[6,7,8,9,10,11] Published reports that evaluated topiramate-associated hyperchloremic, normal anion-gap, metabolic acidosis were identified via a MEDLINE search (1966-May 2007) and included six ...

The plasma concentration of sodium ions normally exceeds the sum of the plasma concentrations of chloride and bicarbonate ions. Calculation of the resulting 'anion gap' can aid the diagnosis of ...

When a person has too much acid or too little alkali in their blood, the anion gap reading will be higher than normal. This is called “high anion gap metabolic acidosis,” and it can be life ...

When common causes of mixed, normal or large anion gap metabolic acidosis have been ruled out, a comprehensive review of less common causes should be considered. D-lactic acidosis should be considered ...

A normal osmolar gap is considered less than 10 mOsm/L and an osmolar gap of more than 20 mOsm/L can suggest the presence of a low-molecular-weight solute like an alcohol in the plasma.

Metabolic Acidosis Associated With An Increased Mortality Rate Date: February 11, 2006 Source: BioMed Central Summary: Critically ill patients with metabolic acidosis are twice as likely to die as ...

Critically ill patients with metabolic acidosis are twice as likely ... but it is also considerable for patients with strong ion gap (SIG) acidosis ... acidosis due to an excess of unidentified ions.

A serum osmolal gap was normal, but there was an elevated plasma lactic acid concentration of 6.4 mM. ... The differential diagnosis of anion gap acidosis is summarized in Figure 1; ...

After four days of treatment, the patient's acidosis was worse (pH, 6.9; bicarbonate level, 6.2 mmol per liter; anion gap, 17.8 mmol per liter), despite a slow improvement in the lactate level (to ...

Conclusion: After receiving increased dosages of topiramate, a 37-year-old man developed hyperchloremic, normal anion-gap, metabolic acidosis, which resolved after discontinuation of the drug.