Protein expression during G1/S transition in RCC. Examples of immunohistochemistry staining of cyclin D1, D3, E, and p27 are shown in Figure 1 and data are summarised in Table 1.The formalin-fixed ...

N-myc regulates p27 levels through an increase in targeting of p27 to the proteasome via cyclin E kinase-dependent phosphorylation of p27 and its ubiquitination. N-myc also stimulates an increase ...

What is the prognostic significance of p27 expression in cancer, and will it play a major role as a target for future therapy? News & Perspective Drugs & Diseases ...

At univariate analysis, anatomic site, tumor extension, clinical stage, high cyclin D1 expression, and low p27 expression were significantly associated with reduced disease-free and overall survival ...

The cyclin-dependent kinase (CDK) inhibitor p27 kip1 (CDKN1B) is known to be a tumor suppressor, however, it may also function as an oncogene within the cytoplasm by affecting cell motility and ...

The presence of p27, a cyclin-dependent kinase inhibitor that powerfully blocks progression of the cell cycle, 1 in the nucleus of a variety of tumor cells has been correlated with improved ...

Modulation of restriction point regulators p21/p27 or cyclin D1 enables short-term rescue of proliferation under methionine and leucine withdrawal, and to a lesser extent lysine withdrawal, revealing ...

What is the prognostic significance of p27 expression in cancer, and will it play a major role as a target for future therapy? What is the prognostic significance of p27 expression in cancer, ...

Accelerated Radiotherapy, Carbogen, and Nicotinamide in Glioblastoma Multiforme: Report of European Organization for Research and Treatment of Cancer Trial 22933 PURPOSE: To investigate the prognostic ...