(A) CyclinD1 gene expression follows the pattern of Low-High-Low, in response to increasing dose of p27, suggesting that Ccnd1 is highly expressed at the intermediate level of p27 dosage. (B) Model ...

p27 may not be a tumor-suppressor gene, but p27 now certainly seems to be a tumor-suppressor protein. From the standpoint of cancer therapy opportunities, there is an enormous difference in this ...

The expression of the cyclin-dependent kinase inhibitor (CDKI) p27 protein was investigated in relation to (1) the expression of the cell cycle regulators p53, Rb and p16 and (2) the proliferation ...

This study suggests that constitutive activation of the PI3K-Akt pathway mediates TGF- resistance. TGF- - and IL-6-sensitive cells were rendered resistant by ectopic Akt activation. Akt activity ...

PURPOSE: To investigate the prognostic relevance of p21 and p27 protein expression in laryngeal squamous cell carcinoma (LSCC). PATIENTS AND METHODS: ... Expression of p21 and p27 was not correlated ...