"Our assembloid reconstructs the liver periportal region and can model aspects of cholestatic liver injury and biliary fibrosis. We chose this region in particular since it plays a key role in ...

Existing tissue-derived liver organoid models consist of only one cell type and fail to replicate the complex cellular composition and tissue architecture, such as the liver periportal region.

Periportal assembloid, with the three component cell types visualized: cholangiocytes in pink, portal fibroblasts in green, and hepatocyte nuclei in blue; all cell borders are visualized in white ...

Liver disease modelling: This liver model reconstructs the liver periportal region architecture, is able to model aspects of cholestatic liver injury and biliary fibrosis, ...

New tissue-derived organoid model: A next-generation organoid model, composed of three liver cell types – adult hepatocytes, cholangiocytes, and liver mesenchymal cells – reconstructs the ...

To the point. New tissue-derived organoid model: A next-generation organoid model, composed of three liver cell types – adult hepatocytes, cholangiocytes, and liver mesenchymal cells – reconstructs ...