More information: Jory A. Goldsmith et al, Structural basis for neutralizing antibody binding to pertussis toxin, Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas ...

TOPLINE: A booster dose of recombinant pertussis vaccines provides sustained immunity in adolescents and young adults even after 5 years, with pertussis toxin (PT)–neutralizing antibody levels ...

There was a significant blunting of pertussis toxin neutralizing activity, serum bactericidal activity, total pertussis-specific antibody binding, and memory B-cell responses among DTwP-vaccinated ...

Whooping cough, or pertussis, was once a leading cause of death for children in the U.S. and worldwide before the introduction of vaccines in the 1940s. In the decades since, the bacterial disease ...