More information: Huachun Cui et al, TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity, Nature Communications (2025). DOI: 10.1038/s41467-025-57024-0 ...

Looking specifically at alveolar macrophage cells under a microscope, the researchers measured the sizes of the cells and the amount of carbon accumulated in the cells. They found that the average ...

James Baker, Sophie Booth, Josiah Dungwa, Andrew Higham, Dave Singh, Simon Lea. Alveolar macrophage carbon is associated with COPD severity. ERJ Open Research , 2025; 00933-2024 DOI: 10.1183 ...

Our lead program, molgramostim nebulizer solution, is an inhaled granulocyte-macrophage colony-stimulating factor (GM-CSF) in Phase 3 development for autoimmune pulmonary alveolar proteinosis (aPAP).

TREM2, a cell surface receptor on monocyte-derived alveolar macrophages (Mo-AMs), is highly expressed in fibrotic lungs and promotes macrophage survival and lung fibrosis by delaying apoptosis.

The UAB researchers showed that TREM2 — which stands for triggering receptors expressed on myeloid cells 2 — is predominantly expressed on monocyte-derived alveolar macrophages in bleomycin-induced ...