RNA splicing, a process discovered in the late 1970s, ... In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron.

Now, his team has discovered that two important regulator proteins work together to keep the splicing process on track. One of those regulators, a protein called SRSF1, has been a focus of Krainer ...

Raghu R. Chivukula, MD, Ph.D., a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic ...

This “toxic RNA” depletes the protein and prevents it from binding to other RNA molecules in important areas of the genome, causing a protein imbalance which results in mis-splicing other genes.

RNA splicing, a process discovered in the late 1970s, ... In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron.

RNA splicing is a heavy lift, but our cells make it look easy. New research from CSHL Professor Adrian Krainer may help explain how. Krainer’s latest study reveals a previously unseen link ...

RNA splicing ribozymes have been shown to possess a conserved active ... “These RNA-binding small molecules selectively inhibit the two steps of splicing by adopting distinctive poses at ...

Researchers have harnessed a bacterial immune defense system, known as CRISPR, to efficiently and precisely control the process of RNA splicing. The technology opens the door to new applications ...

SPLICE-neo is the first tool to comprehensively identify and prioritize splicing neoantigens from both DNA splice-site mutations and de novo RNA aberrant splicings. There are two major advances of ...

RNA splicing regulation discovery provides insight into bone diseases ... These proteins are involved in the process of mRNA splicing, which is a key step in mRNA metabolism.