RNA splicing ribozymes have been shown to possess a conserved active ... “These RNA-binding small molecules selectively inhibit the two steps of splicing by adopting distinctive poses at ...

RNA splicing, a process discovered in the late 1970s, ... In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron.

RNA splicing, a process discovered in the late 1970s, ... In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron.

RNA splicing is a heavy lift, but our cells make it look easy. New research from CSHL Professor Adrian Krainer may help explain how. Krainer’s latest study reveals a previously unseen link ...

This “toxic RNA” depletes the protein and prevents it from binding to other RNA molecules in important areas of the genome, causing a protein imbalance which results in mis-splicing other genes.

RNA splicing regulation discovery provides insight into bone diseases ... These proteins are involved in the process of mRNA splicing, which is a key step in mRNA metabolism.

Now, his team has discovered that two important regulator proteins work together to keep the splicing process on track. One of those regulators, a protein called SRSF1, has been a focus of Krainer ...

To summarize, the study identified RNA splicing errors as a major source of tumor-specific neoantigens in gliomas, offering new opportunities for targeted immunotherapy.

In a new study, researchers demonstrate that deregulation of a protein called RBFOX2, involved in RNA splicing, contributes to the progression and metastasis of pancreatic cancer.

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are ...