C&EN2y
The Discovery of Sotorasib (AMG 510): First-in-Class Investigational Covalent Inhibitor of KRAS G12C
Join Brian Lanman of Amgen as he outlines the strategies used to overcome these challenges, the screening approaches employed to identify starting points for these efforts, and the optimization ...
Business Insider1mon
Verastem announces preliminary avutometinib and sotorasib data
Verastem (VSTM) announced preliminary clinical data for the triplet combination of avutometinib and sotorasib plus defactinib in the RAMP 203 Phase 1/2 study in KRAS G12C mutant advanced non-small ...
AZoQuantum on MSN5mon
Quantum Computing Enhances Drug Discovery
Sotorasib, a covalent inhibitor targeting this ... energy profile calculations/profiling of covalent bond cleavage for ...
Hosted on MSN1mon
Chinese scientists’ quantum computing pipeline could change the way drugs are designed
To determine whether their quantum computing pipeline could be used to study this, the researchers investigated the anticancer prodrug ... another anticancer drug, sotorasib, known as a KRAS ...
Business Wire1mon
Verastem Oncology Provides a Clinical Update for RAMP 203 Trial in Advanced KRAS G12C Mutant Non-Small Cell Lung Cancer
“Recently, we added defactinib to the combination of avutometinib and sotorasib in our RAMP 203 trial. Preliminary data for the triplet combination have shown a generally favorable tolerability ...