The current study is the first to report the persistence and re-engraftment of GZMK-expressing CD8+ T-cell clones in nasal polyp tissues that promote tissue inflammation and recurrent airway diseases.

Researchers have discovered a way to make the immune system’s T cells significantly more effective at fighting cancer. By ...

Investigators led by Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and ...

In cell culture assays, ApoE4 CD8+ T cells wriggled across a layer of brain endothelial cells more efficiently than did their E3 counterparts. In the brains of 6-month-old mice, Halters noticed that ...

About the study A CD8+ T cell atlas was created using data from 68 studies, 961 single-cell immune profiling samples, and over 1.1 million cells across 42 conditions.

In addition, researchers found that targeting BFAR could not only revive the antitumor activity of aged CD8+ T cells, but also enhance the sensibility of PD-1 blockade-based immunotherapy.

In fighting chronic infections or certain cancers, CD8+ T cells—the immune system's frontline soldiers—eventually become ...

Like elephants, stem cell-like CD8+ T cells have the ability to 'remember' previous infections and respond rapidly to threats. The team harnessed immunomodulation, to adjust immune responses at ...

It keeps CD8 T cells in a "ready-to-learn" state. When B cells are absent, FOXO1 levels drop and the T cells fail to develop into long-lasting memory cells.

In humanized mice, a single intravenous dose of 10 or 30 µg CD8-L829-tLNP-CD19 induced near-complete B cell depletion within three hours, with measurable CAR expression on CD8 + T cells ...