In 1986, T.R. Mosmann, R.L. Coffman, and colleagues observed that individual clones of helper T cells could be separated into two classes depending upon the specific cytokines the cells secrete in ...

T-cells within the small intestine lamina propria, particularly T helper 1 (Th1) cells, prevent the development of cancer in the small intestine. Lower T-cell counts were observed among AFD-fed ...

Soquelitinib has been shown to affect T cell differentiation and induce the generation of Th1 helper cells while blocking the development of both Th2 and Th17 cells and production of their secreted ...

During infections, the immune system needs to distinguish foreign antigens that are expressed by invading bacteria and ...

Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression.

Gene expression is regulated by transcription factors in concert with epigenetic modifications (such as DNA methylation, post-translational histone modifications, the position and compaction of ...

Discovering the transcription factors that direct lineage commitment in the T helper cell was a formidable task. Laurie Glimcher describes how she and Susanne Szabo hunted down T-bet, a ...

In conclusion, Tim-3 was characterized as a novel immune checkpoint molecule with pathophysiological significance in respiratory oncology. Its stage-dependent expression dynamics and multimodal ...