Kidney stones affect nearly 10% of the global population. For more than three decades, thiazide diuretics, a common medication used for high blood pressure, have been the standard of care for ...

Mendelian Randomization Analysis of Genetic Proxies of Thiazide Diuretics and the Reduction of Kidney Stone Risk. JAMA Network Open , 2023; 6 (11): e2343290 DOI: 10.1001/jamanetworkopen.2023.43290 ...

Effect size: decrease in blood pressure after thiazide treatment. Studies are listed in chronological order and divided into single genes, gene interactions and genome-wide association studies ...

Given that thiazide diuretics bind to NCC from outside the cell 2, we hypothesized that wild-type NCC might not be suitable for determining the polythiazide-bound structure.

Thiazide diuretics, commonly prescribed to prevent kidney stone recurrence, are drugs that act directly on the kidneys to promote diuresis (urine flow) ...