Mendelian Randomization Analysis of Genetic Proxies of Thiazide Diuretics and the Reduction of Kidney Stone Risk. JAMA Network Open , 2023; 6 (11): e2343290 DOI: 10.1001/jamanetworkopen.2023.43290 ...

Kidney stones affect nearly 10% of the global population. For more than three decades, thiazide diuretics, a common medication used for high blood pressure, have been the standard of care for ...

Effect size: decrease in blood pressure after thiazide treatment. Studies are listed in chronological order and divided into single genes, gene interactions and genome-wide association studies ...

Given that thiazide diuretics bind to NCC from outside the cell 2, we hypothesized that wild-type NCC might not be suitable for determining the polythiazide-bound structure.

Thiazide diuretics, commonly prescribed to prevent kidney stone recurrence, are drugs that act directly on the kidneys to promote diuresis (urine flow) ...