A new paper from MUSC Hollings Cancer Center researchers is helping to reveal the "rules" for engineering chimeric antigen receptor (CAR) Tregs. Tregs, or T-regulatory cells, have shown promise in ...

Full receptor occupancy at 1 mg/kg or greater, durable for >28 days, no Treg expansion or activation of CD3 T cells observed; and Differentiation from TL1A blocking monoclonal antibodies may yield ...

The complete receptor is usually found on regulatory T (Treg) cells, which dampen an ongoing immune response. By contrast, another receptor composed of only the IL-2β and IL-2γ components is ...

In addition to the donor organ, they had also received bone marrow from the same donor and an infusion of polyclonal (with a large number of different T cell receptors) autologous Treg cells ...