Cancer cells and tumors do not exist in a vacuum. Far from the isolation and self-sufficiency of the fictional Wakanda, ...

de la Calle-Fabregat, C., et al. (2024) NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the immunosuppressive effects of the tumor microenvironment.Science Advances. doi ...

Publication information: “Functional reprogramming of neutrophils within the brain tumor microenvironment by hypoxia-driven histone lactylation,” from Cancer Discovery.

Accurate removal of tumors is the most critical aspect of cancer surgery, yet it remains a significant challenge in clinical ...

A new research paper was published in Volume 16 of Oncotarget on June 25, 2025, titled "Hypoxia induced lipid droplet ...

A new research paper was published in Volume 16 of Oncotarget on June 25, 2025, titled “Hypoxia induced lipid droplet accumulation promotes resistance to ferroptosis in prostate cancer.” ...

Brain tumors pose significant treatment challenges due to their complex structure and the sensitive location within the brain. Surgical options are often ...

Key regulator that induces cancer-killing capacity in T cells under hypoxia is identified Date: December 13, 2024 Source: University of Alabama at Birmingham ...

Pancreatic ductal adenocarcinoma (PDAC) tumors resemble an ecosystem, with up to 80% of the mass consisting of nontumor stromal cells and extracellular matrix (ECM). 1 The PDAC ecosystem consists of ...

Tumor Hypoxia. Biomedicine and Pharmacotherapy 2022. Accessed October 20, 2024. Harris AL. Hypoxia–a key regulatory factor in tumour growth. Nat Rev Cancer. 2002;2(1):38-47. Rankin EB, Giaccia AJ.