Pharmacokinetics. The parameter and OBJs values for the base 1-, 2-, and 3-compartment models are summarized in Table 1.As found in the separate modeling of the intravenous and nasal data, the 2 ...

RESULTS: A linear two-compartment model characterized total topotecan plasma concentrations (n = 899). Four primary pharmacokinetic parameters (total clearance, volume of the central compartment, ...

Pharmacokinetic modeling demonstrated that the formula was reasonably accurate regardless of whether a one- or two-compartment model most accurately described carboplatin pharmacokinetics, assuming ...

Pharmacokinetic Data Analysis. Intravenous Data. Standard 1-, 2-, and 3-compartment models were fitted to the concentration-time data for the intravenous doses.