Recessive dystrophic epidermolysis bullosa (RDEB) is a severe genodermatosis caused by loss-of-function mutations in COL7A1 encoding type VII collagen, the component of anchoring fibrils. As ...

Collagen makes up the tendrils and fibrils that provide a cushion for the skin's cells to rest upon; type VII collagen, in particular, is critical to the creation of the skin's so-called anchoring ...

Collagen makes up the tendrils and fibrils that provide a cushion for the skin's cells to rest upon; type VII collagen, in particular, is critical to the creation of the skin's so-called anchoring ...

The integrity of human skin is partly ensured by type VII collagen, a protein found in anchoring fibrils in the skin's basement membrane zone. Mutations in the type VII collagen gene, ...

In normal skin, three molecules of type VII collagen (C7) polymerize, interact with dermal and epidermal proteins, and form the main component of anchoring fibrils. As a biologic Velcro, anchoring ...

One type of immature cells from bone marrow proved to be the best at producing anchoring fibrils that bind ... skin's ability to produce type VII collagen necessary to anchor the skin and lining ...

It is caused by one or more mutations in a gene called COL7A1, which is responsible for the production of the protein type VII collagen (COL7) that forms anchoring fibrils that bind the dermis ...

It is caused by one or more mutations in a gene called COL7A1, which is responsible for the production of the protein type VII collagen (COL7) that forms anchoring fibrils that bind the dermis ...

Lead product candidate, KB103, shown to successfully transfer COL7A1 gene and to correct recessive dystrophic epidermolysis bullosa (RDEB) PITTSBURGH, May 09, 2018 (GLOBE NEWSWIRE) -- Krystal ...

It is caused by one or more mutations in a gene called COL7A1, which is responsible for the production of the protein type VII collagen (COL7) that forms anchoring fibrils that bind the dermis ...

Based on a variant’s impact on type VII collagen protein function, patients with recessive dystrophic epidermolysis bullosa can be categorized into clinically meaningful subgroups to better ...