Mass spectrometry has become the standard tool to map sites of ubiquitination, which is a covalent protein modification with a central role in regulating cellular processes 1. Ubiquitin is a small ...

Proteins in the cell are subject to diverse covalent modifications that serve to alter their activity, localization, or turnover. Such modifications include ubiquitination and covalent attachment of ...

Ubiquitin is a small, covalent modifier that forms a poly ... Figure 5: Parkin exhibits ubiquitination activity in vitro. Parkin consists of two functionally different domains (Fig.