In a study published in Angewandte Chemie International Edition, a research team integrated activity-based protein profiling ...

Proteins in the cell are subject to diverse covalent modifications that serve to alter their activity, localization, or turnover. Such modifications include ubiquitination and covalent attachment of ...

Mass spectrometry has become the standard tool to map sites of ubiquitination, which is a covalent protein modification with a central role in regulating cellular processes 1. Ubiquitin is a small ...

Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of ...