The urea cycle is the main way that the human body disposes of nitrogen waste. New research suggests that disruptions in this process may be an early sign of cancer. Share on Pinterest Blood ...

The specific symptoms of disorders related to the urea cycle vary among the different types of these disorders. Typically, with complete deficiency of urea cycle enzymes, symptoms present within ...

The treatment of disorders related to the urea cycle is a lifelong process aimed at managing symptoms and doesn't cure the disorder. Strategies include monitoring ammonia levels using blood tests ...

An Indiana University School of Medicine physician scientist is making strides in understanding the molecular origins of fatty liver disease, a leading cause of liver failure in the United States. By ...

The urea cycle is a metabolic pathway used in mammals to incorporate excess nitrogen into urea and remove it from the body. However, it appears to play a far more wide-ranging role in the group of ...

Urea cycle disorders are categorized as inborn errors of metabolism (IEM), which are a group of diseases that are capable of causing brain damage and death in newborns and small children.

Nitric oxide is generated from L-arginine, supplied by the urea cycle (UC). We hypothesized that polymorphisms in UC enzyme genes and low concentrations of UC intermediates are associated with PPHN.

New results reveal the urea cycle in astrocytes as the link between amyloid-beta accumulation and memory loss, providing enzyme ODC1 as a new therapeutic target to treat Alzheimer’s disease Peer ...

Suppressing urea cycle enzymes, particularly ODC1, using short hairpin RNAs halved the amount of putrescine and brought GABA back to levels seen in control astrocytes. In addition, inhibiting ODC1 ...

Scientists have discovered that marine diatoms, tiny phytoplankton abundant in the sea, have an animal-like urea cycle, and that this cycle enables the diatoms to efficiently use carbon and ...