The SNARE proteins reside on the targeting membrane (t-SNAREs) and vesicles (v-SNAREs), respectively. They interact with each other to form a complex of four-helix bundle through their membrane ...

To investigate the v-SNARE dependence of vesicular exocytosis, we transfected astrocytes with fluorescently tagged NPY (using monomeric teal fluorescent protein).

SNARE proteins are known as the minimal machinery for membrane fusion. To induce membrane fusion, the proteins combine to form a SNARE complex in a four helical bundle, and NSF and α-SNAP ...

Biologists at UC Santa Barbara have now discovered a surprising, additional function for syntaxin 3S, a soluble form of a SNARE protein. The researchers found a new signaling pathway widely used ...

Ultimately, we aim to obtain a comprehensive molecular understanding of the CAPA pathway. 2. Chaperone-assisted assembly of SNARE complexes and its roles in metabolism and diabetes. Intracellular ...

The Hsc70 system maintains the synaptic SNARE protein SNAP-25 in an assembly-competent state and delays its aggregation. Journal of Biological Chemistry, 2024; 300 (12): 108001 DOI: 10.1016/j.jbc ...

The team dug deeper and observed not only that Hsc70 help in forming SNARE, it actually combines with SNAP-25 into a protein complex. That complex is what keeps SNAP-25 in the correct form for SNARE.

Numerous proteins initiate and regulate the process in the cells: more than 40 different types have already been identified. However their molecular functions are still largely unknown.

Daniel Garcia Cabanillas a, Jun Jiang a, Nooshin Movahed b, Hugo Germain c, Yasuyuki Yamaji d, Huanquan Zheng b, Jean-François Laliberté a, Turnip Mosaic Virus Uses the SNARE Protein VTI11 in an ...

Emory scientists map ‘spiderweb’ of lung cancer proteins to snare new drug targets By Arlene Weintraub Feb 17, 2017 3:12pm CDK inhibitors lung cancer Oncology Emory University ...