This mammalian homologue of the yeast protein Sec1 binds directly and tightly to the t-SNARE on the presynaptic plasma membrane, syntaxin-1A; moreover, binding of n-Sec1 to syntaxin-1A blocks v ...

The yeast proteins Sro7 and Sro77, and their metazoan relatives Lgl and tomosyn, interact with plasma membrane SNARE proteins and control cell polarity. Recently, the crystal structure of yeast ...